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2 1 JDMM BMI200320152015BMI25BMI22 303402 GLP-12GLP-1GLP-1 GLP-1111GLP-1 GLP-1 GLP-12 GLP-1 GLP-1 2GLP-1 GLP-1 210GLP-14GLP-1 GLP-1 2393GLP-14 GLP-1GLP-1DPP-4 :LiraglutideDPP-42 3827(5,032)129(2,091)24HbA1cHbA1c 0.9mg:LiraglutideDPP-4(:Vildagliptin:Sitagliptin:Linagliptin:Alogliptin:Teneligliptin:Trelagliptin:Omarigliptin) 2:Liraglutide0.9mgDPP-4 1HbA1c7% GLP-1HbA1c1HbA1c7.0%CCPI,100C/HbA1c7.0%SU1.861.10 GLP-1 GLP-1 GLP-1GLP-1GLP-1 BMI 25kg/m257 150mg/dL2200mg/dL0.3mg/10.3mg/0.9mg/ GLP-1 GLP-12 GLP-1212GLP-1371.59kg GLP-1 GLP-1 GLP-1LEADERSUSTAIN-6 24 24 14GLP-1DPP4GLP-1GLP-1GLP-1 GLP-14 2 SU10 UKPDS24,209 SU2,729met3421,13810 Holman RR et al.N Engl J Med 359(15)1577-1589, 2008 21013159242 50% GLP-130 GLP-1 23HbA1c7%1,168 HbA1c7%6Hb1Ac7% Pantalone KM, et al

A phase 2 study (MARIPOSA randomized trial) demonstrated that, in patients with OSA, administration of aroxybutynin (an antimuscarinic agent) combined with atomoxetine (a norepinephrine reuptake inhibitor) led to modest but significant reductions in AHI (AHI reduction of 5.9 events/hour greater than placebo) over a 4-week period, though the use of atomoxetine was also associated with a reduction of total sleep time by approximately 21 min